PF3D7_1473600

Genome location: Pf3D7_14_v3:2,996,429..2,998,275(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.02	0.99
Trophozoite	expressed	0.16	0.90
Schizont	expressed	0.01	1.00
Gametocyte	expressed	0.02	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1473600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.124 | MFS: -2.739 | #Insertions: 0

PlasmoGEM Phenotype: Insufficient data (Pb ortholog: PBANKA_1336800)

Relative Growth Rate: nan ± nan
Confidence: 0.10

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKA1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532335

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	8	1	8
disruptive	0	3	1	8
missense	0	3	1	8

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	10	6	9
disruptive	0	11	15	42
missense	0	10	13	26

PlasmoDB Total SNPs: 100

Non-coding: 97 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 114 | Molecular Weight (kDa): 12.565

UniProt ID(s): Q8IKA1

PDB ID(s): None

Isoelectric Point: 5.15

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A