Genome location: Pf3D7_14_v3:2,998,294..3,004,891(-)
Genome classification: Core
Product Description: nucleoporin NUP116/NSP116, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0044613 | nuclear pore central transport channel |
| Component | GO:0005634 | nucleus |
| Function | GO:0003690 | double-stranded DNA binding |
| Function | GO:0017056 | structural constituent of nuclear pore |
| Function | GO:0003712 | transcription coregulator activity |
| Process | GO:0006606 | protein import into nucleus |
| Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.16 | 0.93 |
| Trophozoite | not expressed | 0.11 | 0.95 |
| Schizont | not expressed | 0.05 | 0.97 |
| Gametocyte | not expressed | 0.56 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1473700
Resistome Missense Mutations: S218N, D222H, D222E, T224K
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.796 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKA0
"Best" AlphaFill ligand hit: SRT (s,r meso-tartaric acid, Local RMSD=0.79) with 1XXN (Global RMSD=15.07)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 42 | 19 | 54 |
| disruptive | 52 | 115 | 40 | 149 |
| missense | 42 | 93 | 36 | 117 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 79 | 35 | 59 |
| disruptive | 89 | 221 | 117 | 258 |
| missense | 68 | 166 | 84 | 142 |
PlasmoDB Total SNPs: 507
Non-coding: 219 | Synonymous: 187 | Nonsynonymous: 98 | Stop Codon: 3
Protein Length: 1253 | Molecular Weight (kDa): 142.21
UniProt ID(s): Q8IKA0
PDB ID(s): None
Isoelectric Point: 8.35
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 23475702 | Nuclear pores and perinuclear expression sites of var and ribosomal DNA genescorrespond to physically distinct regions in Plasmodium falciparum. | Guizetti J, Martins RM, ..., Scherf A | 10.1128/EC.00023-13 |
| 25041160 | Cbc2p, Upf3p and eIF4G are components of the DRN (Degradation of mRNA in theNucleus) in Saccharomyces cerevisiae | Das S, Saha U, Das B | 10.1111/1567-1364.12180 |
| 30263842 | Diversity analysis of Saccharomyces cerevisiae isolated from natural sources bymultilocus sequence typing (MLST) | Eeom YJ, Son SY, ..., Park CS | 10.1007/s10068-018-0335-z |
| 22544723 | Atomic structure of the nuclear pore complex targeting domain of a Nup116homologue from the yeast, Candida glabrata | Sampathkumar P, Kim SJ, ..., Burley SK | 10.1002/prot.24102 |
| 27862252 | Specific populations of the yeast Geotrichum candidum revealed by moleculartyping | Jacques N, Mallet S, ..., Casaregola S | 10.1002/yea.3223 |