Genome location: Pf3D7_14_v3:3,006,482..3,010,275(+)
Genome classification: Core
Product Description: ribosome assembly 1 protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.57 | 0.73 |
| Trophozoite | expressed | 0.26 | 0.85 |
| Schizont | expressed | 0.18 | 0.88 |
| Gametocyte | possibly expressed | 0.68 | 0.63 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1473900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.999 | MFS: -2.129 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1337000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK99
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 51 | 38 | 69 |
| disruptive | 52 | 246 | 114 | 262 |
| missense | 32 | 195 | 100 | 206 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 137 | 36 | 65 |
| disruptive | 123 | 484 | 171 | 389 |
| missense | 82 | 378 | 135 | 197 |
PlasmoDB Total SNPs: 166
Non-coding: 59 | Synonymous: 49 | Nonsynonymous: 57 | Stop Codon: 1
Protein Length: 852 | Molecular Weight (kDa): 101.283
UniProt ID(s): Q8IK99
PDB ID(s): 7QDW
Isoelectric Point: 8.74
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR019496 | Nuclear fragile X mental retardation-interacting protein 1, conserved domain |
| PFam | PF10453 | Nuclear fragile X mental retardation-interacting protein 1, conserved domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 35315277 | Structural Analysis of the Plasmodial Proteins ZNHIT3 and NUFIP1 ProvidesInsights into the Selectivity of a Conserved Interaction. | Chagot ME, Boutilliat A, Kriznik A, Quinternet M | 10.1021/acs.biochem.1c00792 |