About Gene List

PF3D7_1474000

Genome location: Pf3D7_14_v3:3,010,871..3,020,375(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.97
Trophozoite not expressed 0.13 0.93
Schizont not expressed 0.11 0.94
Gametocyte expressed 1.44 0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1474000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.36 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK98

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533745

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 23 133 79 174
disruptive 143 460 212 476
missense 93 384 191 390

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 45 282 114 158
disruptive 245 875 286 607
missense 149 727 244 389

PlasmoDB Total SNPs: 492

Non-coding: 198 | Synonymous: 154 | Nonsynonymous: 140 | Stop Codon: 0

Protein Information

Protein Length: 2104 | Molecular Weight (kDa): 248.705

UniProt ID(s): Q8IK98

PDB ID(s): None

Isoelectric Point: 6.29

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104