Product Description: ribosomal protein L20, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0000315 | organellar large ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000027 | ribosomal large subunit assembly |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.09 | 0.94 |
| Schizont | expressed | 0.01 | 1.00 |
| Gametocyte | possibly expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1474100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.155 | MFS: -3.638 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK97
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101985
Most Similar Human Ortholog: Q9BYC9
TM-align score: 0.88 | RMSD: 1.66
Seq Identity: 0.25 | Length: 116 / 121
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000242485 | mitochondrial ribosomal protein L20 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 6 | 3 | 8 |
| disruptive | 0 | 3 | 3 | 15 |
| missense | 0 | 3 | 3 | 15 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 19 | 3 | 9 |
| disruptive | 1 | 12 | 10 | 34 |
| missense | 1 | 10 | 10 | 30 |
PlasmoDB Total SNPs: 100
Non-coding: 95 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 121 | Molecular Weight (kDa): 14.732
UniProt ID(s): Q8IK97
PDB ID(s): None
Isoelectric Point: 11.12
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005813 | Ribosomal protein L20 |
| InterPro | IPR035566 | Ribosomal protein L20, C-terminal |
| PFam | PF00453 | Ribosomal protein L20 |
| Superfamily | SSF74731 | Ribosomal protein L20, C-terminal |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |