PF3D7_1474400

Genome location: Pf3D7_14_v3:3,044,129..3,055,248(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.13	0.94
Trophozoite	not expressed	0.28	0.85
Schizont	not expressed	0.26	0.85
Gametocyte	expressed	1.65	0.38

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1474400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.978 | #Insertions: 6

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1301800)

Relative Growth Rate: 0.02 ± 0.06
Confidence: 7.02

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532376

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	42	170	90	204
disruptive	149	590	307	656
missense	110	513	276	561

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	69	320	132	234
disruptive	286	1186	435	829
missense	189	982	357	595

PlasmoDB Total SNPs: 735

Non-coding: 328 | Synonymous: 194 | Nonsynonymous: 213 | Stop Codon: 0

Protein Information

Protein Length: 2977 | Molecular Weight (kDa): 357.806

UniProt ID(s): Q8IK94

PDB ID(s): None

Isoelectric Point: 9.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A