Genome location: Pf3D7_14_v3:3,055,333..3,059,095(-)
Genome classification: Core
Product Description: splicing factor 3A subunit 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005686 | U2 snRNP |
| Component | GO:0071004 | U2-type prespliceosome |
| Component | GO:0071013 | catalytic step 2 spliceosome |
| Component | GO:0005634 | nucleus |
| Component | GO:0005681 | spliceosomal complex |
| Function | GO:0003723 | RNA binding |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.50 | 0.75 |
| Trophozoite | expressed | 0.71 | 0.60 |
| Schizont | expressed | 0.38 | 0.76 |
| Gametocyte | expressed | 0.74 | 0.60 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1474500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.126 | MFS: -2.958 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK93
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102246
Most Similar Human Ortholog: F8WB66
TM-align score: 0.35 | RMSD: 4.49
Seq Identity: 0.02 | Length: 44 / 701
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000099995 | splicing factor 3a subunit 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 38 | 28 | 54 |
| disruptive | 31 | 115 | 53 | 147 |
| missense | 18 | 89 | 45 | 122 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 83 | 36 | 56 |
| disruptive | 59 | 228 | 100 | 193 |
| missense | 35 | 180 | 75 | 132 |
PlasmoDB Total SNPs: 216
Non-coding: 139 | Synonymous: 35 | Nonsynonymous: 41 | Stop Codon: 1
Protein Length: 701 | Molecular Weight (kDa): 83.749
UniProt ID(s): Q8IK93
PDB ID(s): None
Isoelectric Point: 5.13
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000061 | SWAP/Surp |
| InterPro | IPR022030 | Splicing factor 3A subunit 1 |
| InterPro | IPR035967 | SWAP/Surp superfamily |
| PFam | PF01805 | SWAP/Surp |
| PFam | PF12230 | Splicing factor 3A subunit 1 |
| Superfamily | SSF109905 | SWAP/Surp superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |