Genome location: Pf3D7_14_v3:3,059,611..3,062,656(+)
Genome classification: Core
Product Description: vacuole membrane protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 6
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0012505 | endomembrane system |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0016020 | membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.25 | 0.87 |
| Trophozoite | expressed | 0.32 | 0.80 |
| Schizont | expressed | 0.13 | 0.91 |
| Gametocyte | expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1474600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.137 | MFS: -2.956 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK92
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103371
Most Similar Human Ortholog: Q96GC9
TM-align score: 0.77 | RMSD: 3.67
Seq Identity: 0.28 | Length: 367 / 394
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000062716 | vacuole membrane protein 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 26 | 17 | 24 |
| disruptive | 3 | 20 | 14 | 24 |
| missense | 3 | 20 | 14 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 44 | 24 | 26 |
| disruptive | 8 | 50 | 33 | 87 |
| missense | 7 | 35 | 24 | 56 |
PlasmoDB Total SNPs: 132
Non-coding: 114 | Synonymous: 14 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 394 | Molecular Weight (kDa): 46.19
UniProt ID(s): Q8IK92
PDB ID(s): None
Isoelectric Point: 8.8
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR032816 | SNARE associated Golgi protein |
| PFam | PF09335 | SNARE associated Golgi protein |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |