PF3D7_1474700

Genome location: Pf3D7_14_v3:3,063,191..3,065,763(-)

Genome classification: Core

Function and Localization

Product Description: protein kinase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.96
Trophozoite	not expressed	0.21	0.87
Schizont	not expressed	0.07	0.96
Gametocyte	not expressed	0.62	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1474700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.433 | #Insertions: 5

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1301500)

Relative Growth Rate: 0.17 ± 0.04
Confidence: 7.62

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1301500)

Modification: Disrupted | RMgm-3404

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK91

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.24) with 3PFQ (Global RMSD=4.41)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127997

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	54	25	50
disruptive	24	140	69	166
missense	22	133	67	147

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	91	40	60
disruptive	63	269	122	214
missense	46	235	107	170

PlasmoDB Total SNPs: 73

Non-coding: 21 | Synonymous: 27 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 753 | Molecular Weight (kDa): 91.58

UniProt ID(s): Q8IK91

PDB ID(s): None

Isoelectric Point: 10.15

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000719	Protein kinase domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR011009	Protein kinase-like domain superfamily
PFam	PF00069	Protein kinase domain
Superfamily	SSF56112	Protein kinase-like domain superfamily