Genome location: Pf3D7_14_v3:3,069,615..3,073,847(+)
Genome classification: Core
Product Description: trailer hitch homolog, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0043186 | P granule |
| Component | GO:0000932 | P-body |
| Component | GO:0005737 | cytoplasm |
| Component | GO:1990124 | messenger ribonucleoprotein complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0033962 | P-body assembly |
| Process | GO:0006402 | mRNA catabolic process |
| Process | GO:0034063 | stress granule assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.07 | 0.95 |
| Schizont | expressed | 0.03 | 0.97 |
| Gametocyte | expressed | 0.10 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1474900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.348 | MFS: -2.492 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_0626300)
Modification: Tagged | RMgm-1551
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK89
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102881
Most Similar Human Ortholog: I3L4Q1
TM-align score: 0.74 | RMSD: 2.18
Seq Identity: 0.62 | Length: 85 / 328
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000257103 | LSM14A mRNA processing body assembly factor |
| ENSG00000262860 | LSM14A mRNA processing body assembly factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 26 | 12 | 16 |
| disruptive | 4 | 13 | 4 | 20 |
| missense | 1 | 11 | 4 | 18 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 43 | 13 | 24 |
| disruptive | 5 | 37 | 23 | 98 |
| missense | 2 | 29 | 19 | 64 |
PlasmoDB Total SNPs: 189
Non-coding: 174 | Synonymous: 10 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 328 | Molecular Weight (kDa): 38.569
UniProt ID(s): Q8IK89
PDB ID(s): None
Isoelectric Point: 9.8
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010920 | LSM domain superfamily |
| InterPro | IPR019050 | FDF domain |
| InterPro | IPR025609 | Lsm14-like, N-terminal |
| PFam | PF12701 | Lsm14-like, N-terminal |
| Superfamily | SSF50182 | LSM domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20169188 | Universal features of post-transcriptional gene regulation are critical forPlasmodium zygote development. | Mair GR, Lasonder E, ..., Waters AP | 10.1371/journal.ppat.1000767 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 34604117 | Roles and Cellular Localization of GBP2 and NAB2 During the Blood Stage ofMalaria Parasites | Niikura M, Fukutomi T, Mitobe J, Kobayashi F | 10.3389/fcimb.2021.737457 |
| 38352447 | Global Release of Translational Repression Across Plasmodium's Host-to-VectorTransmission Event | Rios KT, McGee JP, ..., Lindner SE | 10.1101/2024.02.01.577866 |
| 38148574 | The Plasmodium falciparum CCCH zinc finger protein MD3 regulates malegametocytogenesis through its interaction with RNA-binding proteins | Farrukh A, Musabyimana JP, ..., Ngwa CJ | 10.1111/mmi.15215 |