Genome location: Pf3D7_14_v3:3,075,788..3,076,186(+)
Genome classification: Core
Product Description: mediator of RNA polymerase II transcription subunit 31, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070847 | core mediator complex |
| Component | GO:0016592 | mediator complex |
| Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.00 | 1.00 |
| Trophozoite | possibly expressed | 0.01 | 0.99 |
| Schizont | not expressed | 0.00 | 1.00 |
| Gametocyte | not expressed | 0.01 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1475000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.162 | MFS: -2.601 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK88
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103162
Most Similar Human Ortholog: Q9Y3C7
TM-align score: 0.71 | RMSD: 1.96
Seq Identity: 0.36 | Length: 104 / 132
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000108590 | mediator complex subunit 31 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 6 | 2 | 6 |
| disruptive | 1 | 3 | 4 | 9 |
| missense | 1 | 3 | 4 | 8 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 10 | 2 | 9 |
| disruptive | 2 | 13 | 14 | 15 |
| missense | 1 | 12 | 13 | 8 |
PlasmoDB Total SNPs: 15
Non-coding: 0 | Synonymous: 13 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 132 | Molecular Weight (kDa): 16.606
UniProt ID(s): Q8IK88
PDB ID(s): None
Isoelectric Point: 8.55
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008831 | Mediator complex, subunit Med31 |
| PFam | PF05669 | Mediator complex, subunit Med31 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 35557691 | Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates withEvolutionarily Novel Subunits. | Iyer UB, Park JE, ..., Featherstone M | 10.1021/acsomega.2c00368 |
| 37014863 | Yeast PIC-Mediator structure with RNA polymerase II C-terminal domain | Schilbach S, Wang H, Dienemann C, Cramer P | 10.1073/pnas.2220542120 |