PF3D7_1475100

Genome location: Pf3D7_14_v3:3,076,187..3,081,459(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005813	centrosome
Component	GO:0005737	cytoplasm
Component	GO:0005634	nucleus
Component	GO:0000922	spindle pole
Process	GO:0000278	mitotic cell cycle
Process	GO:0032465	regulation of cytokinesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.29	0.86
Trophozoite	expressed	0.70	0.61
Schizont	possibly expressed	0.28	0.83
Gametocyte	expressed	0.56	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1475100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.038 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1301100)

Relative Growth Rate: 0.11 ± 0.04
Confidence: 7.85

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK87

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532837

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	118	47	112
disruptive	70	285	170	357
missense	56	251	152	314

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	194	61	117
disruptive	136	591	243	501
missense	97	491	202	335

PlasmoDB Total SNPs: 166

Non-coding: 25 | Synonymous: 78 | Nonsynonymous: 63 | Stop Codon: 0

Protein Information

Protein Length: 1526 | Molecular Weight (kDa): 185.912

UniProt ID(s): Q8IK87

PDB ID(s): None

Isoelectric Point: 9.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A