PF3D7_1475200

Genome location: Pf3D7_14_v3:3,081,750..3,084,635(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0071013	catalytic step 2 spliceosome
Function	GO:0003723	RNA binding
Process	GO:0000390	spliceosomal complex disassembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	not expressed	0.54	0.69
Schizont	not expressed	0.11	0.93
Gametocyte	not expressed	0.38	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1475200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.89 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK86

"Best" AlphaFill ligand hit: FON (n-{[4-({[(6r)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-l-glutamic acid, Local RMSD=2.08) with 4XCZ (Global RMSD=32.08)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533062

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	60	25	64
disruptive	40	160	97	208
missense	37	155	95	199

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	104	34	63
disruptive	62	346	136	242
missense	53	321	121	201

PlasmoDB Total SNPs: 85

Non-coding: 0 | Synonymous: 44 | Nonsynonymous: 41 | Stop Codon: 0

Protein Information

Protein Length: 961 | Molecular Weight (kDa): 115.395

UniProt ID(s): Q8IK86

PDB ID(s): None

Isoelectric Point: 8.07

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007502	Helicase-associated domain
InterPro	IPR011709	Domain of unknown function DUF1605
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF04408	Helicase-associated domain
PFam	PF07717	Domain of unknown function DUF1605
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase