Genome location: Pf3D7_14_v3:3,085,179..3,087,302(+)
Genome classification: Core
Product Description: cytochrome c oxidase assembly protein COX11, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 1.9.3.1 (Transferred entry: 7.1.1.9)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031304 | intrinsic component of mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0008535 | respiratory chain complex IV assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.36 | 0.77 |
| Schizont | expressed | 0.08 | 0.95 |
| Gametocyte | expressed | 0.23 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1475300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.145 | MFS: -2.887 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1300900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK85
"Best" AlphaFill ligand hit: C2F (5-methyl-5,6,7,8-tetrahydrofolic acid, Local RMSD=2.85) with 3IJD (Global RMSD=17.30)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.9.3.1 | cytochrome-c oxidase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102743
Most Similar Human Ortholog: Q9Y6N1
TM-align score: 0.52 | RMSD: 1.15
Seq Identity: 0.55 | Length: 121 / 228
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000166260 | cytochrome c oxidase copper chaperone COX11 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 125
Non-coding: 120 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 228 | Molecular Weight (kDa): 26.807
UniProt ID(s): Q8IK85
PDB ID(s): None
Isoelectric Point: 8.7
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007533 | Cytochrome c oxidase assembly protein CtaG/Cox11 |
| InterPro | IPR023471 | Cytochrome c oxidase assembly protein CtaG/Cox11, domain superfamily |
| PFam | PF04442 | Cytochrome c oxidase assembly protein CtaG/Cox11 |
| Superfamily | SSF110111 | Cytochrome c oxidase assembly protein CtaG/Cox11, domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 37348640 | Expression and copper binding studies of a Plasmodium falciparum protein withCox19 copper binding motifs | Salman AA, Goldring JPD | 10.1016/j.exppara.2023.108572 |
| 35666203 | A yeast suppressor screen links Coa4 to the mitochondrial copper delivery pathwayfor cytochrome c oxidase | Swaminathan AB, Soma S, ..., Gohil VM | 10.1093/genetics/iyac090 |
| 35672733 | Expression and copper binding characteristics of Plasmodium falciparum cytochromec oxidase assembly factor 11, Cox11 | Salman AA, Goldring JPD | 10.1186/s12936-022-04188-5 |
| 38068960 | Novel COX11 Mutations Associated with Mitochondrial Disorder: FunctionalCharacterization in Patient Fibroblasts and Saccharomyces cerevisiae | Caron-Godon CA, Della Vecchia S, ..., Nesti C | 10.3390/ijms242316636 |