Genome location: Pf3D7_14_v3:3,087,061..3,105,071(-)
Genome classification: Core
Product Description: cysteine repeat modular protein 4
SignalP Peptide: MKNITFLVSFLIFLRSINA
# Transmembrane Domains: 10
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031362 | anchored component of external side of plasma membrane |
| Process | GO:0030522 | intracellular receptor signaling pathway |
| Process | GO:0046907 | intracellular transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.09 | 0.96 |
| Trophozoite | not expressed | 0.34 | 0.83 |
| Schizont | not expressed | 0.30 | 0.84 |
| Gametocyte | not expressed | 0.64 | 0.68 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1475400
Resistome Missense Mutations: A551D
Resistome Compounds with Missense Mutations: MMV668399
Resistome # Samples with Disruptive Mutations: 4 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.971 | #Insertions: 27
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1445700)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1300800)
Modification: Disrupted | RMgm-5065
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 59 | 271 | 145 | 323 |
| disruptive | 260 | 632 | 350 | 783 |
| missense | 153 | 518 | 302 | 670 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 110 | 458 | 237 | 362 |
| disruptive | 433 | 1199 | 512 | 1111 |
| missense | 259 | 943 | 434 | 862 |
PlasmoDB Total SNPs: 572
Non-coding: 49 | Synonymous: 275 | Nonsynonymous: 248 | Stop Codon: 0
Protein Length: 5906 | Molecular Weight (kDa): 700.918
UniProt ID(s): Q8IK84
PDB ID(s): None
Isoelectric Point: 8.25
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| InterPro | IPR011641 | Tyrosine-protein kinase ephrin type A/B receptor-like |
| InterPro | IPR033489 | E3 ubiquitin-protein ligase RBBP6 family |
| PFam | PF07699 | Tyrosine-protein kinase ephrin type A/B receptor-like |
| Superfamily | SSF57184 | Growth factor receptor cysteine-rich domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 17253978 | Plasmodium cysteine repeat modular proteins 1-4: complex proteins with rolesthroughout the malaria parasite life cycle. | Thompson J, Fernandez-Reyes D, ..., Waters AP | 10.1111/j.1462-5822.2006.00885.x |