Genome location: Pf3D7_14_v3:3,112,433..3,116,035(-)
Genome classification: Core
Product Description: bromodomain protein 4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.57 | 0.72 |
| Trophozoite | possibly expressed | 0.42 | 0.75 |
| Schizont | possibly expressed | 0.25 | 0.84 |
| Gametocyte | possibly expressed | 0.25 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1475600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.734 | MFS: -0.468 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK82
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9H8M2 | Bromodomain-containing protein 9 | OrthoDB, OrthoMCL BLAST | US10150767, Example 3US10150767, Example 5US10150767, Example 6US10150767, Example 11... | |
| Q9NPI1 | Bromodomain-containing protein 7 | Homo sapiens | OrthoDB, OrthoMCL BLAST | CHEMBL2177300CHEMBL3824133CHEMBL3823101CHEMBL3823551... |
| Q3UQU0 | Bromodomain-containing protein 9 | OrthoDB, OrthoMCL BLAST | CHEMBL3823478 |
Protein Length: 729 | Molecular Weight (kDa): 85.803
UniProt ID(s): Q8IK82
Isoelectric Point: 7.15
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001487 | Bromodomain |
| InterPro | IPR036427 | Bromodomain-like superfamily |
| PFam | PF00439 | Bromodomain |
| Superfamily | SSF47370 | Bromodomain-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 20 | 5 | 23 |
| disruptive | 24 | 59 | 34 | 91 |
| missense | 18 | 54 | 34 | 83 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 29 | 24 | 37 |
| disruptive | 34 | 145 | 77 | 178 |
| missense | 25 | 121 | 61 | 113 |
PlasmoDB Total SNPs: 89
Non-coding: 49 | Synonymous: 21 | Nonsynonymous: 19 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |