About Gene List

PF3D7_1475800

Genome location: Pf3D7_14_v3:3,120,854..3,121,849(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.00 1.00
Trophozoite possibly expressed 0.01 1.00
Schizont expressed 0.12 0.93
Gametocyte possibly expressed 0.01 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1475800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.976 | MFS: -2.732 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A7A0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533384

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 6 5 11
disruptive 106 36 10 28
missense 91 31 10 23

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 13 7 10
disruptive 121 46 19 39
missense 102 40 16 28

PlasmoDB Total SNPs: 99

Non-coding: 2 | Synonymous: 12 | Nonsynonymous: 85 | Stop Codon: 0

Protein Information

Protein Length: 309 | Molecular Weight (kDa): 34.14

UniProt ID(s): A0A144A7A0, A0A650D6D5, A0A650D6E5, A0A650D6E7, A0A650D6F0, A0A650D6F5, A0A650D6F8, A0A650D6G2, A0A650D6G5, A0A650D6H1, A0A650D6H2, A0A650D6H7, A0A650D6H8, A0A650D6I4, A0A650D6J0, A0A650D6J4, A0A650D6K5, A0A650D6P3, A0A650D6R1

PDB ID(s): None

Isoelectric Point: 4.23

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104