About Gene List

PF3D7_1475900

Genome location: Pf3D7_14_v3:3,124,298..3,126,709(+)

Genome classification: Core

Function and Localization

Product Description: KELT protein

SignalP Peptide: MAYLKKLFLILFCMYVPKKA

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.00 1.00
Trophozoite not expressed 0.01 1.00
Schizont not expressed 0.00 1.00
Gametocyte not expressed 0.03 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1475900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.703 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8Y2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532884

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 17 7 21
disruptive 114 55 24 53
missense 105 49 22 40

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 24 15 21
disruptive 126 80 27 78
missense 114 67 18 63

PlasmoDB Total SNPs: 127

Non-coding: 0 | Synonymous: 29 | Nonsynonymous: 98 | Stop Codon: 0

Protein Information

Protein Length: 803 | Molecular Weight (kDa): 94.235

UniProt ID(s): A0A5K1K8Y2

PDB ID(s): None

Isoelectric Point: 5.09

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104