PF3D7_1476200

Genome location: Pf3D7_14_v3:3,133,352..3,136,491(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTb), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020036	Maurer's cleft
Component	GO:0044538	host cell periphery

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.62	0.78
Trophozoite	expressed	0.96	0.62
Schizont	expressed	0.15	0.93
Gametocyte	possibly expressed	0.33	0.82

More info:

Old (Pf3D7v3) Gene ID: PF3D7_1476200

Resistome Missense Mutations: N453K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 6 (6 missense, 0 "interesting" missense)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.233 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

AlphaFill Uniprot ID: Q8IK76

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Ortholog Group (OrthoMCL): OG6_532686

No human ortholog(s)

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	12	10	18
disruptive	33	87	52	106
missense	24	60	42	80

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	27	9	22
disruptive	54	174	70	162
missense	33	117	54	104

PlasmoDB Total SNPs: 174

Non-coding: 122 | Synonymous: 24 | Nonsynonymous: 28 | Stop Codon: 0

Protein Length: 512 | Molecular Weight (kDa): 61.473

UniProt ID(s): Q8IK76

PDB ID(s): None

Isoelectric Point: 6.91

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006526	Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR019111	Plasmodium RESA, N-terminal
PFam	PF09687	Plasmodium RESA, N-terminal
Superfamily	SSF48371	Armadillo-type fold

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
25106850	A conserved domain targets exported PHISTb family proteins to the periphery ofPlasmodium infected erythrocytes.	Tarr SJ, Moon RW, Hardege I, Osborne AR	10.1016/j.molbiopara.2014.07.011
27777305	Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates NovelLocalization Sequences That Target the Periphery of the Host Erythrocyte.	Davies HM, Thalassinos K, Osborne AR	10.1074/jbc.M116.761213
31631203	A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum.	Das D, Krishnan SR, Roy A, Bulusu G	10.1039/c9mo00124g