About Gene List

PF3D7_1476600

Genome location: Pf3D7_14_v3:3,149,879..3,155,508(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044538 host cell periphery

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.03 0.98
Trophozoite possibly expressed 0.06 0.97
Schizont not expressed 0.02 0.99
Gametocyte expressed 0.73 0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1476600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.992 | MFS: -1.994 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK70

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532406

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 81 32 62
disruptive 94 269 109 220
missense 78 237 100 188

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 28 116 34 60
disruptive 151 409 144 266
missense 129 359 124 192

PlasmoDB Total SNPs: 325

Non-coding: 174 | Synonymous: 60 | Nonsynonymous: 90 | Stop Codon: 1

Protein Information

Protein Length: 955 | Molecular Weight (kDa): 110.987

UniProt ID(s): Q8IK70

PDB ID(s): None

Isoelectric Point: 4.38

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
27777305 Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates NovelLocalization Sequences That Target the Periphery of the Host Erythrocyte. Davies HM, Thalassinos K, Osborne AR 10.1074/jbc.M116.761213