About Gene List

PF3D7_1477100

Genome location: Pf3D7_14_v3:3,172,816..3,173,905(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp6), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed nd 1.00
Trophozoite not expressed 0.00 1.00
Schizont not expressed 0.00 1.00
Gametocyte not expressed 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1477100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.331 | MFS: -2.671 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A4N4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160725

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 17 11 9
disruptive 20 76 29 60
missense 19 69 20 51

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 25 6 12
disruptive 42 118 51 71
missense 38 101 36 37

PlasmoDB Total SNPs: 58

Non-coding: 33 | Synonymous: 5 | Nonsynonymous: 20 | Stop Codon: 0

Protein Information

Protein Length: 194 | Molecular Weight (kDa): 23.018

UniProt ID(s): A0A144A4N4

PDB ID(s): None

Isoelectric Point: 9.15

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006410 Conserved hypothetical protein CHP01519, Plasmodium falciparum (isolate 3D7)
PFam PF09715 Conserved hypothetical protein CHP01519, Plasmodium falciparum (isolate 3D7)
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12