Genome location: Pf3D7_14_v3:3,178,340..3,181,155(+)
Genome classification: Core
Product Description: Plasmodium exported protein (PHIST), unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030430 | host cell cytoplasm |
| Component | GO:0020003 | symbiont-containing vacuole |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.01 | 0.99 |
| Schizont | expressed | 0.00 | 1.00 |
| Gametocyte | not expressed | 0.08 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1477300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.191 | MFS: -2.786 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK62
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 28 | 9 | 24 |
| disruptive | 9 | 46 | 24 | 50 |
| missense | 6 | 39 | 23 | 47 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 37 | 13 | 16 |
| disruptive | 15 | 91 | 22 | 79 |
| missense | 9 | 80 | 21 | 60 |
PlasmoDB Total SNPs: 132
Non-coding: 96 | Synonymous: 17 | Nonsynonymous: 19 | Stop Codon: 0
Protein Length: 280 | Molecular Weight (kDa): 32.791
UniProt ID(s): Q8IK62
PDB ID(s): None
Isoelectric Point: 9.13
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006526 | Exported protein, PHISTa/b/c, conserved domain, Plasmodium |
| InterPro | IPR019111 | Plasmodium RESA, N-terminal |
| PFam | PF09687 | Plasmodium RESA, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15996767 | Identification of a subtelomeric gene family expressed during the asexual-sexualstage transition in Plasmodium falciparum. | Eksi S, Haile Y, ..., Williamson KC | 10.1016/j.molbiopara.2005.05.010 |