About Gene List

PF3D7_1477500

Genome location: Pf3D7_14_v3:3,187,707..3,191,551(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTb), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.63 0.75
Trophozoite expressed 0.54 0.75
Schizont expressed 0.08 0.96
Gametocyte not expressed 0.28 0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1477500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.964 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK60

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_131849

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 8 8 21
disruptive 30 39 18 39
missense 22 32 14 35

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 17 12 29
disruptive 40 68 38 71
missense 28 50 33 39

PlasmoDB Total SNPs: 206

Non-coding: 132 | Synonymous: 26 | Nonsynonymous: 46 | Stop Codon: 2

Protein Information

Protein Length: 500 | Molecular Weight (kDa): 60.553

UniProt ID(s): Q8IK60

PDB ID(s): None

Isoelectric Point: 7.44

Protein Domain Annotations:

Source Family ID Description
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
33774908 Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. Jonsdottir TK, Counihan NA, ..., Gilson PR 10.1111/cmi.13332