Genome location: Pf3D7_14_v3:3,192,675..3,199,877(+)
Genome classification: Core
Product Description: surface-associated interspersed protein 14.1 (SURFIN 14.1)
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0044228 | host cell surface |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.97 |
| Trophozoite | possibly expressed | 0.06 | 0.97 |
| Schizont | possibly expressed | 0.02 | 0.99 |
| Gametocyte | not expressed | 0.21 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1477600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.615 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A325
"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=0.12) with 2VS3 (Global RMSD=20.87)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 11 | 9 | 21 |
| disruptive | 84 | 83 | 28 | 101 |
| missense | 79 | 67 | 24 | 86 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 22 | 20 | 16 | 22 |
| disruptive | 102 | 136 | 53 | 124 |
| missense | 91 | 98 | 47 | 81 |
PlasmoDB Total SNPs: 572
Non-coding: 78 | Synonymous: 179 | Nonsynonymous: 313 | Stop Codon: 2
Protein Length: 1953 | Molecular Weight (kDa): 239.531
UniProt ID(s): A0A144A325, A0A348FV57, A0A348FV68, A0A348FV77
PDB ID(s): None
Isoelectric Point: 5.08
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR024288 | Schizont-infected cell agglutination, C-terminal domain |
| PFam | PF12879 | Schizont-infected cell agglutination, C-terminal domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15939796 | SURFIN is a polymorphic antigen expressed on Plasmodium falciparum merozoites andinfected erythrocytes. | Winter G, Kawai S, ..., Wahlgren M | 10.1084/jem.20041392 |
| 33901679 | Plasmodium falciparum SURFIN(4.1) forms an intermediate complex with PTEXcomponents and Pf113 during export to the red blood cell. | Miyazaki S, Chitama BA, ..., Kaneko O | 10.1016/j.parint.2021.102358 |