PF3D7_1477700 (Pfg14-748)

Genome location: Pf3D7_14_v3:3,201,236..3,204,592(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTa), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020003	symbiont-containing vacuole

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.04	0.98
Trophozoite	expressed	0.05	0.98
Schizont	expressed	0.02	0.99
Gametocyte	expressed	1.09	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1477700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.172 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK58

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=7.33) with 6MT9 (Global RMSD=21.14)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179324

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	12	7	20
disruptive	13	24	15	41
missense	11	23	14	40

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	19	18	23
disruptive	18	58	23	67
missense	13	54	20	54

PlasmoDB Total SNPs: 209

Non-coding: 184 | Synonymous: 9 | Nonsynonymous: 15 | Stop Codon: 1

Protein Information

Protein Length: 291 | Molecular Weight (kDa): 34.478

UniProt ID(s): Q8IK58

PDB ID(s): None

Isoelectric Point: 6.77

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006526	Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro	IPR019111	Plasmodium RESA, N-terminal
PFam	PF09687	Plasmodium RESA, N-terminal
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
15996767	Identification of a subtelomeric gene family expressed during the asexual-sexualstage transition in Plasmodium falciparum.	Eksi S, Haile Y, ..., Williamson KC	10.1016/j.molbiopara.2005.05.010