Genome location: Pf3D7_14_v3:3,207,055..3,208,478(+)
Genome classification: Core
Product Description: acyl-CoA binding protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.03 | 0.99 |
| Trophozoite | not expressed | 0.00 | 1.00 |
| Schizont | expressed | 0.00 | 1.00 |
| Gametocyte | not expressed | 0.00 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1477800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.899 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1427500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK57
"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=0.17) with 1HBK (Global RMSD=0.47)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103494
Most Similar Human Ortholog: Q5T8E0
TM-align score: 0.91 | RMSD: 1.52
Seq Identity: 0.31 | Length: 90 / 90
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000107897 | acyl-CoA binding domain containing 5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 75
Non-coding: 73 | Synonymous: 0 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 90 | Molecular Weight (kDa): 10.724
UniProt ID(s): Q8IK57
PDB ID(s): 1HBK
Isoelectric Point: 5.86
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000582 | Acyl-CoA-binding protein, ACBP |
| InterPro | IPR035984 | Acyl-CoA binding protein superfamily |
| PFam | PF00887 | Acyl-CoA-binding protein, ACBP |
| Superfamily | SSF47027 | Acyl-CoA binding protein superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34956931 | Merozoite Proteins Discovered by qRT-PCR-Based Transcriptome Screening ofPlasmodium falciparum. | Hou N, Li S, ..., Chen Q | https://pubmed.ncbi.nlm.nih.gov/34956931/ |