Genome location: Pf3D7_14_v3:3,213,312..3,215,049(+)
Genome classification: Core
Product Description: Plasmodium exported protein (PHISTa), unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0043657 | host cell |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 2.48 | 0.24 |
| Trophozoite | not expressed | 0.51 | 0.77 |
| Schizont | not expressed | 0.40 | 0.79 |
| Gametocyte | not expressed | 0.65 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1478000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -3.106 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK55
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 9 | 4 | 20 |
| disruptive | 16 | 42 | 21 | 45 |
| missense | 13 | 42 | 20 | 43 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 20 | 9 | 21 |
| disruptive | 23 | 82 | 25 | 81 |
| missense | 19 | 74 | 22 | 52 |
PlasmoDB Total SNPs: 75
Non-coding: 48 | Synonymous: 10 | Nonsynonymous: 17 | Stop Codon: 0
Protein Length: 282 | Molecular Weight (kDa): 33.418
UniProt ID(s): Q8IK55
PDB ID(s): None
Isoelectric Point: 8.33
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006526 | Exported protein, PHISTa/b/c, conserved domain, Plasmodium |
| InterPro | IPR019111 | Plasmodium RESA, N-terminal |
| PFam | PF09687 | Plasmodium RESA, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
| 16507167 | Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. | Sargeant TJ, Marti M, ..., Cowman AF | 10.1186/gb-2006-7-2-r12 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |