About Gene List

PF3D7_1478100

Genome location: Pf3D7_14_v3:3,216,275..3,217,794(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp13), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.30 0.85
Trophozoite possibly expressed 0.06 0.97
Schizont expressed 0.09 0.94
Gametocyte expressed 0.10 0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1478100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.149 | MFS: -3.159 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK54

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215319

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 11 6 12
disruptive 16 25 22 31
missense 16 25 22 27

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 23 7 20
disruptive 18 72 34 48
missense 18 57 27 33

PlasmoDB Total SNPs: 75

Non-coding: 53 | Synonymous: 7 | Nonsynonymous: 14 | Stop Codon: 1

Protein Information

Protein Length: 247 | Molecular Weight (kDa): 28.656

UniProt ID(s): Q8IK54

PDB ID(s): None

Isoelectric Point: 9.87

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12