About Gene List

PF3D7_1478600 (PTP3)

Genome location: Pf3D7_14_v3:3,231,222..3,237,075(+)

Genome classification: Core

Function and Localization

Product Description: EMP1-trafficking protein

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0030430 host cell cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.45 0.81
Trophozoite expressed 0.34 0.84
Schizont possibly expressed 0.09 0.95
Gametocyte not expressed 0.09 0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1478600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.016 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK49

"Best" AlphaFill ligand hit: ABH (2(s)-amino-6-boronohexanoic acid, Local RMSD=3.14) with 3MMR (Global RMSD=33.45)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_144120

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 21 6 14
disruptive 50 72 22 47
missense 41 65 18 35

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 26 14 26
disruptive 79 115 54 127
missense 62 87 38 52

PlasmoDB Total SNPs: 432

Non-coding: 102 | Synonymous: 190 | Nonsynonymous: 140 | Stop Codon: 0

Protein Information

Protein Length: 1263 | Molecular Weight (kDa): 143.85

UniProt ID(s): Q8IK49

PDB ID(s): None

Isoelectric Point: 9.54

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
18614010 Exported proteins required for virulence and rigidity of Plasmodiumfalciparum-infected human erythrocytes. Maier AG, Rug M, ..., Cowman AF 10.1016/j.cell.2008.04.051
36870684 Two activating phosphorylation sites of Pbs2 MAP2K in the yeast HOG pathway aredifferentially dephosphorylated by four PP2C phosphatases Ptc1-Ptc4 Tatebayashi K, Saito H 10.1016/j.jbc.2023.104569
32389298 Crosstalk between Saccharomycescerevisiae SAPKs Hog1 and Mpk1 is mediated byglycerol accumulation Laz EV, Lee J, Levin DE 10.1016/j.funbio.2019.10.002
30036623 Chemical characterization and antioxidant activities of polysaccharides isolatedfrom the stems of Parthenocissus tricuspidata Liang X, Gao Y, ..., Zhang W 10.1016/j.ijbiomac.2018.07.131
29846136 Intracellular mechanism by which arsenite activates the yeast stress MAPK Hog1 Lee J, Levin DE 10.1091/mbc.E18-03-0185