About Gene List

PF3D7_1478800

Genome location: Pf3D7_14_v3:3,242,408..3,244,072(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: MNKFFLFLHFILGLFNS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.12 0.94
Trophozoite expressed 0.02 0.99
Schizont expressed 0.02 0.99
Gametocyte not expressed 0.01 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1478800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.993 | MFS: -2.391 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK47

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532398

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 14 4 8
disruptive 16 42 35 58
missense 11 39 28 47

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 18 9 14
disruptive 24 86 35 68
missense 18 74 30 40

PlasmoDB Total SNPs: 52

Non-coding: 19 | Synonymous: 12 | Nonsynonymous: 17 | Stop Codon: 4

Protein Information

Protein Length: 198 | Molecular Weight (kDa): 24.073

UniProt ID(s): Q8IK47

PDB ID(s): None

Isoelectric Point: 7.5

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006410 Conserved hypothetical protein CHP01519, Plasmodium falciparum (isolate 3D7)
PFam PF09715 Conserved hypothetical protein CHP01519, Plasmodium falciparum (isolate 3D7)
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g