PF3D7_1479200

Genome location: Pf3D7_14_v3:3,260,745..3,261,727(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: Plasmodium exported protein (PHISTa), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1479200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.827 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK45

"Best" AlphaFill ligand hit: I3P (d-myo-inositol-1,4,5-triphosphate, Local RMSD=1.28) with 3V0H (Global RMSD=16.10)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110760

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 48

Non-coding: 8 | Synonymous: 14 | Nonsynonymous: 22 | Stop Codon: 4

Protein Information

Protein Length: 284 | Molecular Weight (kDa): 33.969

UniProt ID(s): Q8IK45

PDB ID(s): None

Isoelectric Point: 6.16

Protein Domain Annotations: