About Gene List

PF3D7_1479500

Genome location: Pf3D7_14_v3:3,269,494..3,270,496(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: stevor

SignalP Peptide: MKMYYLKMLLFTFLINTLILP

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Process GO:0020013 modulation by symbiont of host erythrocyte aggregation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.00 1.00
Trophozoite not expressed 0.00 1.00
Schizont not expressed 0.00 1.00
Gametocyte not expressed 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1479500

Resistome Missense Mutations: Y102S, G105S, L114I

Resistome Compounds with Missense Mutations: AN13762, AN13956, Desoxyepothilone B

Resistome # Samples with Disruptive Mutations: 6 (6 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.274 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK43

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109391

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 562

Non-coding: 53 | Synonymous: 176 | Nonsynonymous: 329 | Stop Codon: 4

Protein Information

Protein Length: 299 | Molecular Weight (kDa): 33.737

UniProt ID(s): Q2XR66, Q2XR68, Q8IK43

PDB ID(s): None

Isoelectric Point: 8.59

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006374 Variant surface antigen Stevor
PFam PF17410 Variant surface antigen Stevor
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
12477793 Small variant STEVOR antigen is uniquely located within Maurer's clefts inPlasmodium falciparum-infected red blood cells. Kaviratne M, Khan SM, Jarra W, Preiser PR 10.1128/EC.1.6.926-935.2002
25011110 STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediatesmerozoite invasion and rosetting. Niang M, Bei AK, ..., Preiser PR 10.1016/j.chom.2014.06.004