Genome location: Pf3D7_API_v3:1,667..2,239(+)
Genome classification: Apicoplast
Product Description: 50S ribosomal protein L4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0046677 | response to antibiotic |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | nd | nd |
| Trophozoite | no data | nd | nd |
| Schizont | no data | nd | nd |
| Gametocyte | no data | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PFC10_API0043
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: N/A
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q25805
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 3
Non-coding: 0 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 190 | Molecular Weight (kDa): 23.125
UniProt ID(s): Q25805
PDB ID(s): None
Isoelectric Point: 10.58
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002136 | Ribosomal protein L4/L1e |
| InterPro | IPR013005 | 50S ribosomal protein uL4 |
| InterPro | IPR023574 | Ribosomal protein L4 domain superfamily |
| PFam | PF00573 | Ribosomal protein L4/L1e |
| Superfamily | SSF52166 | Ribosomal protein L4 domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 17110371 | In vitro efficacy, resistance selection, and structural modeling studiesimplicate the malarial parasite apicoplast as the target of azithromycin. | Sidhu AB, Sun Q, ..., Fidock DA | 10.1074/jbc.M608615200 |
| 27458998 | Transcripts in the Plasmodium Apicoplast Undergo Cleavage at tRNAs and Editing,and Include Antisense Sequences. | Nisbet RER, Kurniawan DP, Bowers HD, Howe CJ | 10.1016/j.protis.2016.06.003 |
| 8757284 | Complete gene map of the plastid-like DNA of the malaria parasite Plasmodiumfalciparum. | Wilson RJ, Denny PW, ..., Williamson DH | 10.1006/jmbi.1996.0449 |