Genome location: Pf3D7_API_v3:2,467..3,204(+)
Genome classification: Apicoplast
Product Description: apicoplast ribosomal protein L2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0032543 | mitochondrial translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | nd | nd |
| Trophozoite | no data | nd | nd |
| Schizont | no data | nd | nd |
| Gametocyte | no data | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PFC10_API0041
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: N/A
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q25807
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 19
Non-coding: 0 | Synonymous: 15 | Nonsynonymous: 3 | Stop Codon: 1
Protein Length: 245 | Molecular Weight (kDa): 28.736
UniProt ID(s): Q25807
PDB ID(s): None
Isoelectric Point: 10.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002171 | Ribosomal protein L2 |
| InterPro | IPR008991 | Translation protein SH3-like domain superfamily |
| InterPro | IPR022666 | Ribosomal Proteins L2, RNA binding domain |
| InterPro | IPR022669 | Ribosomal protein L2, C-terminal |
| PFam | PF00181 | Ribosomal Proteins L2, RNA binding domain |
| PFam | PF03947 | Ribosomal protein L2, C-terminal |
| Superfamily | SSF50104 | Translation protein SH3-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 27458998 | Transcripts in the Plasmodium Apicoplast Undergo Cleavage at tRNAs and Editing,and Include Antisense Sequences. | Nisbet RER, Kurniawan DP, Bowers HD, Howe CJ | 10.1016/j.protis.2016.06.003 |
| 8757284 | Complete gene map of the plastid-like DNA of the malaria parasite Plasmodiumfalciparum. | Wilson RJ, Denny PW, ..., Williamson DH | 10.1006/jmbi.1996.0449 |