About Gene List

PF3D7_API01700 (RPS3)

Genome location: Pf3D7_API_v3:3,507..4,151(+)

Genome classification: Apicoplast

Function and Localization

Product Description: ribosomal protein S3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0022627 cytosolic small ribosomal subunit
Function GO:0003735 structural constituent of ribosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data nd nd
Trophozoite no data nd nd
Schizont no data nd nd
Gametocyte no data nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PFC10_API0039

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: N/A

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q25809

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532426

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 7

Non-coding: 0 | Synonymous: 2 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 214 | Molecular Weight (kDa): 26.589

UniProt ID(s): Q25809

PDB ID(s): None

Isoelectric Point: 10.06

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001351 Ribosomal protein S3, C-terminal
InterPro IPR036419 Ribosomal protein S3, C-terminal domain superfamily
PFam PF00189 Ribosomal protein S3, C-terminal
Superfamily SSF54821 Ribosomal protein S3, C-terminal domain superfamily

Associated Publications

PMID Title Authors DOI/Link
27458998 Transcripts in the Plasmodium Apicoplast Undergo Cleavage at tRNAs and Editing,and Include Antisense Sequences. Nisbet RER, Kurniawan DP, Bowers HD, Howe CJ 10.1016/j.protis.2016.06.003
8757284 Complete gene map of the plastid-like DNA of the malaria parasite Plasmodiumfalciparum. Wilson RJ, Denny PW, ..., Williamson DH 10.1006/jmbi.1996.0449