PF3D7_API02000 (RPL14)

Genome location: Pf3D7_API_v3:4,802..5,158(+)

Genome classification: Apicoplast

Function and Localization

Product Description: apicoplast ribosomal protein L14

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PFC10_API0036

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: N/A

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1346700)

• Relative Growth Rate: 0.10 ± nan
• Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A140KXV7

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100370

Most Similar Human Ortholog: P62829

TM-align score: 0.85 | RMSD: 1.82

Seq Identity: 0.17 | Length: 115 / 118

All Human Orthologs (OrthoMCL):

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 5

Non-coding: 0 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 118 | Molecular Weight (kDa): 14.015

UniProt ID(s): A0A140KXV7

PDB ID(s): None

Isoelectric Point: 10.49

Protein Domain Annotations: