Genome location: Pf3D7_API_v3:7,559..7,927(+)
Genome classification: Apicoplast
Product Description: apicoplast ribosomal protein S12
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005840 | ribosome |
Function | GO:0003735 | structural constituent of ribosome |
Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | no data | N/A | N/A |
Ring | no data | nd | nd |
Trophozoite | no data | nd | nd |
Schizont | no data | nd | nd |
Gametocyte | no data | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PFC10_API0030
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: N/A
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0613400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q25818
"Best" AlphaFill ligand hit: AM2 (4-o-(3alpha-amino-6alpha-((4-amino-4-deoxy-alpha-d-glucopyranosyl)oxy)-2,3,4,5abeta,6,7,8,8aalpha-octahydro-8beta-hydroxy-7beta-(methylamino)pyrano(3,2-b)pyran-2alpha-yl)-2-deoxy-d-streptamine, Local RMSD=0.04) with 4AQY (Global RMSD=0.65)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101451
Most Similar Human Ortholog: O15235
TM-align score: 0.82 | RMSD: 1.44
Seq Identity: 0.42 | Length: 108 / 122
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000128626 | mitochondrial ribosomal protein S12 |
ENSG00000283018 | mitochondrial ribosomal protein S12 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 8
Non-coding: 0 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 122 | Molecular Weight (kDa): 13.944
UniProt ID(s): Q25818
PDB ID(s): None
Isoelectric Point: 11.19
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR005679 | Ribosomal protein S12, bacterial-type |
InterPro | IPR006032 | Ribosomal protein S12/S23 |
InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
PFam | PF00164 | Ribosomal protein S12/S23 |
Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
8757284 | Complete gene map of the plastid-like DNA of the malaria parasite Plasmodiumfalciparum. | Wilson RJ, Denny PW, ..., Williamson DH | 10.1006/jmbi.1996.0449 |
27458998 | Transcripts in the Plasmodium Apicoplast Undergo Cleavage at tRNAs and Editing,and Include Antisense Sequences. | Nisbet RER, Kurniawan DP, Bowers HD, Howe CJ | 10.1016/j.protis.2016.06.003 |