PF3D7_API03600 (ClpM)

Genome location: Pf3D7_API_v3:10,596..12,899(+)

Genome classification: Apicoplast

Function and Localization

Product Description: chaperone protein ClpM

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PFC10_API0060

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: N/A

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A140KXW9

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.87) with 1QVR (Global RMSD=3.12)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_166754

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 31

Non-coding: 0 | Synonymous: 23 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 767 | Molecular Weight (kDa): 91.425

UniProt ID(s): A0A140KXW9, Q4TT78

PDB ID(s): None

Isoelectric Point: 10.04

Protein Domain Annotations: