Genome location: Pf3D7_API_v3:13,661..14,344(-)
Genome classification: Apicoplast
Product Description: 30S ribosomal protein S2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005763 | mitochondrial small ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | nd | nd |
| Trophozoite | no data | nd | nd |
| Schizont | no data | nd | nd |
| Gametocyte | no data | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PFC10_API0018
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: N/A
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q25803
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101759
Most Similar Human Ortholog: Q9Y399
TM-align score: 0.73 | RMSD: 2.00
Seq Identity: 0.15 | Length: 182 / 227
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000122140 | mitochondrial ribosomal protein S2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 7
Non-coding: 0 | Synonymous: 2 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 227 | Molecular Weight (kDa): 27.462
UniProt ID(s): Q25803
PDB ID(s): None
Isoelectric Point: 10.41
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001865 | Ribosomal protein S2 |
| InterPro | IPR005706 | Ribosomal protein S2, bacteria/mitochondria/plastid |
| InterPro | IPR023591 | Ribosomal protein S2, flavodoxin-like domain superfamily |
| PFam | PF00318 | Ribosomal protein S2 |
| Superfamily | SSF52313 | Ribosomal protein S2, flavodoxin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 8757284 | Complete gene map of the plastid-like DNA of the malaria parasite Plasmodiumfalciparum. | Wilson RJ, Denny PW, ..., Williamson DH | 10.1006/jmbi.1996.0449 |
| 27458998 | Transcripts in the Plasmodium Apicoplast Undergo Cleavage at tRNAs and Editing,and Include Antisense Sequences. | Nisbet RER, Kurniawan DP, Bowers HD, Howe CJ | 10.1016/j.protis.2016.06.003 |
| 37751644 | Screening of genes encoding proteins that interact with Nrf2: Probing a cDNAlibrary from Mytilus coruscus using a yeast two-hybrid system | Zhu L, Li Y, ..., Qi P | 10.1016/j.fsi.2023.109112 |