About Gene List

PF3D7_API04200 (rpoC2)

Genome location: Pf3D7_API_v3:14,357..17,238(-)

Genome classification: Apicoplast

Function and Localization

Product Description: DNA-directed RNA polymerase subunit beta'', putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.7.7.6 (DNA-directed RNA polymerase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data nd nd
Trophozoite no data nd nd
Schizont no data nd nd
Gametocyte no data nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PFC10_API0017

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: N/A

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
2.7.7.6 DNA-directed RNA polymerase BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_117225

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 27

Non-coding: 0 | Synonymous: 14 | Nonsynonymous: 12 | Stop Codon: 1

Protein Information

Protein Length: 959 | Molecular Weight (kDa): 117.86

UniProt ID(s): None

PDB ID(s): None

Isoelectric Point: 9.92

Protein Domain Annotations:

Source Family ID Description
InterPro IPR007081 RNA polymerase Rpb1, domain 5
PFam PF04998 RNA polymerase Rpb1, domain 5
Superfamily SSF64484 N/A

Associated Publications

PMID Title Authors DOI/Link
31418692 Apicomplexan-like parasites are polyphyletic and widely but selectively dependenton cryptic plastid organelles Janouskovec J, Paskerova GG, ..., Simdyanov TG 10.7554/eLife.49662
8757284 Complete gene map of the plastid-like DNA of the malaria parasite Plasmodiumfalciparum. Wilson RJ, Denny PW, ..., Williamson DH 10.1006/jmbi.1996.0449
27485555 Transcription of the apicoplast genome. Nisbet RE, McKenzie JL 10.1016/j.molbiopara.2016.07.004
27458998 Transcripts in the Plasmodium Apicoplast Undergo Cleavage at tRNAs and Editing,and Include Antisense Sequences. Nisbet RER, Kurniawan DP, Bowers HD, Howe CJ 10.1016/j.protis.2016.06.003