PF3D7_API04700 (SUFB)

Genome location: Pf3D7_API_v3:22,528..23,940(-)

Genome classification: Apicoplast

Function and Localization

Product Description: iron-sulfur cluster assembly protein SufB

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast
Component	GO:1990229	iron-sulfur cluster assembly complex
Function	GO:0016887	ATP hydrolysis activity
Function	GO:0005515	protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	nd	nd
Trophozoite	no data	nd	nd
Schizont	no data	nd	nd
Gametocyte	no data	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PFC10_API0012

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: N/A

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q25799

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104113

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 23

Non-coding: 0 | Synonymous: 19 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 470 | Molecular Weight (kDa): 55.245

UniProt ID(s): Q25799

PDB ID(s): None

Isoelectric Point: 9.52

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000825	SUF system FeS cluster assembly, SufBD
InterPro	IPR010231	SUF system FeS cluster assembly, SufB
InterPro	IPR037284	SUF system FeS cluster assembly, SufBD superfamily
PFam	PF01458	SUF system FeS cluster assembly, SufBD
Superfamily	SSF101960	SUF system FeS cluster assembly, SufBD superfamily