Genome location: Pf3D7_MIT_v3:734..1,483(-)
Genome classification: Mitochondrial
Product Description: cytochrome c oxidase subunit 3
SignalP Peptide: N/A
# Transmembrane Domains: 6
EC Numbers: 1.9.3.1 (Transferred entry: 7.1.1.9)
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | nd | nd |
| Trophozoite | no data | nd | nd |
| Schizont | no data | nd | nd |
| Gametocyte | no data | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: mal_mito_1
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: N/A
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K958
"Best" AlphaFill ligand hit: LFA (lipid fragment, Local RMSD=0.05) with 8H8R (Global RMSD=11.92)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.9.3.1 | cytochrome-c oxidase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104028
Most Similar Human Ortholog: P00414
TM-align score: 0.66 | RMSD: 2.37
Seq Identity: 0.31 | Length: 182 / 249
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000198938 | mitochondrially encoded cytochrome c oxidase III |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 4
Non-coding: 0 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 249 | Molecular Weight (kDa): 28.648
UniProt ID(s): A0A076N5U0, A0A2P1NGE8, A0A2R3SKU8, A0A5K1K958, G1CTE3, Q35441, Q35446, Q8SK24, Q9MDY3, W0S4G5, W0S5Y3
PDB ID(s): None
Isoelectric Point: 5.1
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000298 | Cytochrome c oxidase subunit III-like |
| InterPro | IPR024791 | Cytochrome c oxidase subunit III |
| InterPro | IPR035973 | Cytochrome c oxidase subunit III-like superfamily |
| PFam | PF00510 | Cytochrome c oxidase subunit III-like |
| Superfamily | SSF81452 | Cytochrome c oxidase subunit III-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 37748768 | Evidence of Submicroscopic Plasmodium knowlesi Mono-Infection in RemoteIndigenous Communities in Kelantan, Peninsular Malaysia | Dian ND, Muhammad AB, ..., Idris ZM | 10.4269/ajtmh.23-0184 |
| 37787788 | Mitochondrial genome amplification of avian haemosporidian parasites fromsingle-infected wildlife samples using a novel nested PCR approach | Musa S | 10.1007/s00436-023-07986-1 |
| 37988339 | Adaptive evidence of mitochondrial genes in Pteromalidae and Eulophidae(Hymenoptera: Chalcidoidea) | Kang N, Hu H | 10.1371/journal.pone.0294687 |
| 38273031 | Phylogenetic relationship of Prohemistomum vivax to other trematodes based on theinternal transcribed spacer region and mitochondrial genes | Abuzeid AMI, Hefni MM, ..., Li G | 10.1007/s00436-024-08126-z |