PF3D7_MIT02100 (COX1)

Genome location: Pf3D7_MIT_v3:1,945..3,471(+)

Genome classification: Mitochondrial

Function and Localization

Product Description: cytochrome c oxidase subunit 1

SignalP Peptide: N/A

# Transmembrane Domains: 13

EC Numbers: 1.9.3.1 (Transferred entry: 7.1.1.9);7.1.1.9 (Cytochrome-c oxidase)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: mal_mito_2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: N/A

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q02766

"Best" AlphaFill ligand hit: LFA (lipid fragment, Local RMSD=0.06) with 8H8S (Global RMSD=1.60)

BRENDA EC Inhibitors:

Orthology to BindingDB Entries:

Orthology Information

Ortholog Group (OrthoMCL): OG6_102770

Most Similar Human Ortholog: P00395

TM-align score: 0.91 | RMSD: 1.03

Seq Identity: 0.46 | Length: 468 / 508

All Human Orthologs (OrthoMCL):

Protein Information

Protein Length: 508 | Molecular Weight (kDa): 56.413

UniProt ID(s): A0A076NB50, A0A089PLQ5, A0A0K0PXJ4, A0A2R3SKE5, A0A3G1S905, A0A3G1S906, A0A3G1S907, A0A3G1S910, A0A3G1S913, A0A3G1S916, A0A3G1S923, A0A5K1K9G8, G1CTE1, G1CTE4, M9V4E9, M9V7K8, Q02766, Q7YFE4, Q7YFE8, Q7YFE9, Q9G6Y0, Q9MDJ2

PDB ID(s): None

Isoelectric Point: 7.17

Protein Domain Annotations:

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 6

Non-coding: 0 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0