Genome location: Pf3D7_MIT_v3:3,492..4,622(+)
Genome classification: Mitochondrial
Product Description: cytochrome b
SignalP Peptide: N/A
# Transmembrane Domains: 8
EC Numbers: 1.10.2.2 (Transferred entry: 7.1.1.8)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | nd | nd |
| Trophozoite | no data | nd | nd |
| Schizont | no data | nd | nd |
| Gametocyte | no data | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: mal_mito_3
Resistome Missense Mutations: M133I, M133V, L144S, F267V
Resistome Compounds with Missense Mutations: Atovaquone
Resistome # Samples with Disruptive Mutations: 13 (13 missense, 13 "interesting" missense)
Zhang Phenotype: N/A
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q7HP03
"Best" AlphaFill ligand hit: PEE (dope, Local RMSD=0.01) with 4D6T (Global RMSD=2.49)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.10.2.2 | quinol-cytochrome-c reductase | No BRENDA inhibitors |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| I2BJW5 | Cytochrome b | OrthoMCL BLAST | Antimycin AAtovaquoneInz-1Inz-2... | |
| P00156 | Cytochrome b | OrthoMCL BLAST | Antimycin AAtovaquoneInz-2Inz-4... | |
| P24964 | Cytochrome b | OrthoMCL BLAST | PYRACLOSTROBINCHEMBL2251795CHEMBL2251793Kresoxim-Methyl... | |
| P00166 | Cytochrome b6-f complex subunit 4 | OrthoMCL BLAST | CHEMBL2228180CHEMBL2228162CHEMBL2228176CHEMBL2228180... |
Ortholog Group (OrthoMCL): OG6_102198
Most Similar Human Ortholog: P00156
TM-align score: 0.93 | RMSD: 1.85
Seq Identity: 0.41 | Length: 367 / 376
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000198727 | mitochondrially encoded cytochrome b |
Protein Length: 376 | Molecular Weight (kDa): 43.377
UniProt ID(s): A0A076N9X1, A0A089PLQ0, A0A2P1NG06, A0A2P1NGA8, Q02768, Q6PPF6, Q7HP01, Q7HP03, W0S5B2, W0S5P5, W0S756, W0S8R4
PDB ID(s): None
Isoelectric Point: 8.67
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005797 | Cytochrome b/b6, N-terminal |
| InterPro | IPR005798 | Cytochrome b/b6, C-terminal |
| InterPro | IPR016174 | Di-haem cytochrome, transmembrane |
| InterPro | IPR036150 | Cytochrome b/b6, C-terminal domain superfamily |
| PFam | PF00032 | Cytochrome b/b6, C-terminal |
| PFam | PF00033 | Cytochrome b/b6, N-terminal |
| Superfamily | SSF81342 | Di-haem cytochrome, transmembrane |
| Superfamily | SSF81648 | Cytochrome b/b6, C-terminal domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 12
Non-coding: 0 | Synonymous: 11 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10898682 | Mutations in Plasmodium falciparum cytochrome b that are associated withatovaquone resistance are located at a putative drug-binding site. | Korsinczky M, Chen N, ..., Cheng Q | 10.1128/AAC.44.8.2100-2108.2000 |
| 31964401 | Late clinical failure associated with cytochrome b codon 268 mutation duringtreatment of falciparum malaria with atovaquone-proguanil in traveller returningfrom Congo. | Massamba L, Madamet M, ..., Pradines B | 10.1186/s12936-020-3126-y |
| 38334685 | Novel phylogenetic clade of avian Haemoproteus parasites (Haemosporida,Haemoproteidae) from Accipitridae raptors, with description of a new Haemoproteusspecies | Harl J, Fauchois A, ..., Duval L | 10.1051/parasite/2023066 |
| 38273031 | Phylogenetic relationship of Prohemistomum vivax to other trematodes based on theinternal transcribed spacer region and mitochondrial genes | Abuzeid AMI, Hefni MM, ..., Li G | 10.1007/s00436-024-08126-z |